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Individuals with the GSTP1*B allele (a single nucleotide (A:G) substitution at position 313 produces an isoleucine to valine conversion) substantially reduced catalytic activity [92, 93] correlates with a diminished potential to detoxify the drug
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In particular, although initial systematic reviews of published literature on the topic put forward a promising effect on management of anemia and failed to demonstrate a significant efficacy in controlling dyslipidemia [83], a recent meta-analysis involving more than 1700 participants failed to confirm the previous findings regarding the effects of L-carnitine on hemoglobin but showed that L-carnitine significantly decreases serum low-density lipoprotein (LDL) and C-reactive protein (CRP)
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