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Collectively, these lipid-driven metabolic checkpoints impair antigen-trafficking and T cell priming capacity, while also shaping DC adaptation to metabolic stress and compromising DC survival within the TME, thereby amplifying tumour-associated immunosuppression
January 2028
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Here we show that Gdap1 –/– MNs have a fragile phenotype prone to degeneration associated with activation of the p38α MAPK, a key player in apoptotic cell death [55]
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