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Some advantages of natural antioxidants and medicinal products are as follows:[65] Good safety profile with limited side effects, good oral bioavailability, patient-friendly dosing regimen (once or twice daily dosing, concentrating in relevant tissues (brain, kidney, and/or vasculature), limited potential for pro-oxidative activity and secondary cell signaling that may limit their effectiveness, mostly inhibition of ROS production rather than quenching ROS post-production, efficacious for hypertension originating from disparate etiologies, pleiotropic effects that go beyond blood pressure lowering and translate into reversal or prevention in progression of end organ damage, and finally limited interactions with the metabolism of concomitant antihypertensive therapies.[65] It seems that antioxidant activity is not the sole cause of these plants in hypertension reduction