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Regarding the signaling pathway that is involved in autophagy induction, the present study demonstrated that PFOS induced ERK1/2 and ER stress activation, leading to autophagy induction with an increased expression of Beclin and LC3BII
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Hyperinsulinemia and chronic inflammation, common in insulin resistance and type 2 diabetes, promote the overexpression and secretion of endothelin-1 (ET-1), a potent endothelium-derived vasoconstrictor
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