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Specific research directions include: Energy metabolism of adipose tissue — studies on the impact of NNMT inhibition on adipocyte energy expenditure and lipid metabolism in obesity models Nicotinamide/NAD⁺ axis — measurements of how inhibition of nicotinamide methylation translates into the availability of substrate for NAD regeneration via the salvage pathway Management of methyl groups — analysis of the impact of NNMT inhibition on the SAM/SAH balance and, secondarily, on other methylation reactions Regeneration and muscle mass — research on the role of NNMT in skeletal muscle satellite cells Structure-activity relationships (SAR) — characterization of 5-Amino-1MQ as a representative of small-molecule NNMT inhibitors in comparative analyzes When designing comparative experiments on the metabolism of adipose tissue, 5-Amino-1MQ is sometimes combined with compounds with a different molecular target – for example, with a lipolytic fragment of growth hormone AOD-9604 or an oral incretin agonist GLP-1 MAX

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Side effects from B12 supplementation are uncommon but may include: Mild gastrointestinal symptoms such as nausea or diarrhoea, typically with very high oral doses Headache or dizziness in some individuals Skin reactions (rash, itching) at injection sites when using intramuscular preparations Rare but serious allergic reactions, including anaphylaxis with injectable forms Hypokalaemia (low potassium) may occur during rapid correction of severe megaloblastic anaemia If you experience symptoms of a severe allergic reaction (difficulty breathing, severe rash, swelling of face or throat) after taking B12, seek immediate medical attention