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Here RD residues Leu419, Leu492, Met529, and Phe531 of one dimeric subunit form hydrophobic packing interactions with the equivalent residues of the neighbouring dimeric subunit (Supplementary Fig
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By elucidating the mechanisms underlying the ALDH2-AMPK-SIRT2 axis and the c-Abl-PKCδ pathway, they offer promising therapeutic targets to enhance β-cell survival, improve insulin secretion, and mitigate insulin resistance in diabetes management [67,68]
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