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Concurrently, pro-inflammatory cytokines regulate the activity of key enzymes in tryptophan metabolism—indoleamine IDO and TDO—promoting the production of kynurenine pathway metabolites such as KYNA
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Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
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