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vigorous exercise) and dietary interventions such as consumption of cruciferous vegetables have also been shown to increase glutathione levels.[26] Recent evidence of the increase in glutathione level and reduction in activity of GSHPX has been observed in experimental-periodontitis rats treated with proanthocyanidins (PC), a type of flavanoid extracted generally from grape seeds, suggests enhanced host resistance and inhibited OS by the dietary supplementation of PC.[81] SFN, a natural product found in cruciferous vegetables, induces Nrf2 dependent AO gene expression by binding to cys151 on Keap-1

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doi: 10.1016/j.freeradbiomed.2005.10.056