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The mitochondria also act as Ca 2+ buffering systems, which when disturbed can not only increase excitotoxic sensitivity but also, by altering essential Ca 2+ waves, will alter neuronal and glial migration.[237] One of the best documented biochemical changes in ASD is a decrease in cellular glutathione (GSH), a major intracellular antioxidant, and an increase in oxidized glutathione (GSSG), resulting in a reduction in the ratio of reduced (active) GSH to inactive GSSG [Figure 9]
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