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Importantly, HPA axis hyperactivity is correlated with negative outcomes and longevity (e.g., memory deficits occur primarily in aged rats showing hippocampal GR loss (84), and the HPA axis hyperactivity seen in aged F344 rats (24 months) is not observed in the more long-lived F344/Brown-Norway strain (36 months)) (147))
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They also disrupt how the brain and muscles work together
The ratio of glutathione reduced (GSH) to glutathione oxidized (GSSG) determines the cellโs redox status
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