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These bacterial systems are typically composed by a transmembrane sensor histidine kinase and a cytoplasmic response regulator, both working together to sense and process external stimuli including nutrients, metal ions, host-derived metabolites and gut specific conditions

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Finally, it was recently suggested that IGF-I has significant characteristics to be a good marker for the insulin resistance syndrome and risk of cardiovascular disease, since logistic regression analysis showed that each unit increase in log-transformed IGF-I concentrations was associated with a 90.5% reduction in the risk of metabolic syndrome [274]