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Gastrointestinal effects lead: nausea, diarrhea, constipation, and vomiting, dose-dependent and clustered during escalation, mostly mild.βΈ Tirzepatide also produces a modest chronic heart-rate rise with a larger escalation-phase peak.ΒΉΒΉ Oral-contraceptive absorption can fall after starting and after each increase, so use backup or non-oral contraception for 4 weeks each time.βΉ Β²Β² What is known about concurrent metformin and tirzepatide use
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