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CrAT deficiency leads to accumulating acetyl-CoA, which exerts an allosteric inhibiting effect on pyruvate dehydrogenase (PDH), a rate-limiting enzyme for pyruvate entry into the Krebs cycle
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The pathway’s flexibility allows macrophages to adapt their metabolism according to their activation state, impacting both pro-inflammatory and anti-inflammatory responses (Dionísio et al., 2023
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