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ROS play crucial roles in various cellular activities, including autophagy, apoptosis, and ER stress 34,35
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Furthermore, declining hormone levels during the late luteal phase weaken the antioxidant capacity of the Nrf2 pathway while activating inflammatory signals, such as the COX-2/PGE2 axis, thus establishing a vicious cycle of "low hormone levels–high oxidative stress–strong inflammation" [47]
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