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Tissue-level changes continue to build through weeks 2-4
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In experimental neuropathic pain models, repeated stimulation has been shown to downregulate pro-inflammatory cytokines (e.g., spinal IL-1β, hippocampal TNF- α ), upregulate IL-10, and suppress microglial and astrocytic activation, thereby fostering adaptive plasticity and reducing hypersensitivity (85, 86)
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