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Calcitonin receptor + RAMP dimerization → AMY1–AMY3 receptor formation Area postrema receptor engagement → brainstem satiety signaling Amylin receptor agonism → delayed gastric emptying in animal models Anti-aggregation modification → solubility and formulation stability Fatty-acid acylation → albumin binding and extended half-life Core Areas of Scientific Investigation Amylin Receptor Subtype Selectivity: the compound is used to probe the relative contribution of AMY1, AMY2, and AMY3 receptors, and to distinguish amylin signaling from calcitonin receptor signaling
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Rev Prat 2018, 68 (5), 515–519
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