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1 Introduction Porcine epidemic diarrhea virus (PEDV), a member of the Coronaviridae family, has an enveloped single-stranded RNA genome of approximately 28.5 kb in size that primarily infects porcine small intestinal epithelial cells, and is capable of replicating in Vero cells to trigger changes in host gene expression patterns ( Iron plays an important role in the replication of many viruses and is also important in maintaining cellular physiology ( GPX4 axis leads to cellular ferroptosis ( Ferroptosis is a non-apoptotic form of cell death that relies on accumulation of intracellular iron and causes elevated toxic lipid peroxides Reactive oxygen species (ROS) ( 1S,3R ) -RSL3 is an inhibitor of glutathione Peroxidase 4 (GPX4) (ferroptosis agonist)

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Size:1 mg

doi: 10.15302/J-FASE-2023489 23