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This is also underlined by reports of a quaternary complex of all four proteins, namely MTR, MTRR, MMACHC, and MMADHC 12
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Group I is coupled to Gq and activates phospholipase C, which produces inositol triphosphate and releases Ca 2+ from intracellular stores in the endoplasmic reticulum, and diacylglycerol activates protein kinase C (47)
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