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Where each drug stands right now If you want the market snapshot in one section, it is this: Semaglutide the established modern GLP-1 benchmark FDA approved broad real-world use still highly effective no longer the ceiling Tirzepatide the current approved leader in weight-loss magnitude FDA approved directly beat semaglutide in SURMOUNT-5 still the most important approved comparator in the field Retatrutide still investigational strongest weight-loss headline of the three mechanistically the most ambitious because of added glucagon activity likely to be one of the most important obesity-market catalysts if late-stage development continues to hold up So which one is “best”